Stopped: No significant differences between 2 study arms
Studies have demonstrated that the use of a procalcitonin (PCT)-guided algorithm in combination with clinical judgment was associated with reduced antibiotic use without impacting mortality or treatment failure. Though several studies have evaluated the use of PCT in critically ill patients, there are limited studies that evaluated PCT in patients with cancer and many of the currently available studies have excluded immune-compromised patients. This is a randomized controlled trial that aims to evaluate the impact of a procalcitonin-guided algorithm on antibiotic utilization in critically ill cancer patients with sepsis. In addition, the study aims to evaluate the predictive value of PCT for predicting mortality and positive cultures.
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Time to antibiotic cessation
Timeframe: 28 days
Number of antibiotic-free days
Timeframe: 28 days