CompletedNot Applicable

Early Healing of Oral Soft Tissues: a Clinical and Biomolecular Analysis. Part I

Italy15 participantsStarted 2019-04-01

Plain-language summary

The purpose of the present study is to observe and compare -through a biomolecular analysis- the differences in the gene expression and cellular behavior in the early wound healing process -24 hours after injury- between the following three oral tissues: alveolar mucosa, buccal gingiva and palatal tissue. The main hypothesis is that there is a difference in the gene expression and in the cellular behaviour between the three oral tissues studied and this difference can be observed at 24 hours post-injury.

Who can participate

Age range30 Years – 60 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * patients that required periodontal surgery; * patients age between 30-60 years; * patients with full mouth plaque score and full mouth bleeding score \< 15%; * patients with a good general healthy status; * patients without any medicaments or drug consumption that can affect the healing process; * non-smoking patients. Exclusion Criteria: * patients in pregnancy; * patients in lactation period; * patients with consumption of antibiotics or anti-inflammatory drugs in the previous six months; * patients with systemic diseases.

What they're measuring

Changes from baseline fold regulation wound healing related genes at 24 hours

Timeframe: Baseline (T0) and 24 hours after surgery (T24)

Trial details

NCT IDNCT04202822

SponsorUniversity of Roma La Sapienza

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-06-06

View on ClinicalTrials.gov More Wound Surgical trials