Not Yet RecruitingPhase 4

Povidone-iodine Irrigation for Prevention of Intra-abdominal Abscess in Pediatric Perforated Appendicitis: a Multi-center Stepped Wedge Cluster Randomized Study

United States1,750 participantsStarted 2027-03-01

Plain-language summary

The purpose of this study is to determine the effect of intra-abdominal irrigation with povidone-iodine (PVI) versus usual care on the rate of 30-day postoperative intra-abdominal abscesses (IAA) and to determine the effect of PVI irrigation versus usual care on 30-day hospital length of stay(LOS) and 30-day readmissions.

Who can participate

Age range2 Years – 17 Years

SexALL

See this in plain English?

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Inclusion Criteria: * Admitted to a participating center * Appendectomy performed for acute appendicitis * Intraoperative diagnosis of perforated appendicitis Exclusion Criteria: * Simple or gangrenous appendicitis * Interval or incidental appendectomy * Initial attempt at non-operative management (defined as \>48 hours between the time of diagnosis and surgical intervention) * History of iodine allergy, thyroid disease or renal dysfunction * Pregnancy

What they're measuring

number of patients with post operative intra-abdominal abscesses

Timeframe: 30 days post surgery

Trial details

NCT IDNCT04200729

SponsorThe University of Texas Health Science Center, Houston

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2030-03-01

Contact for this trial

Kuojen Tsao, MD

(713) 500-7327 KuoJen.Tsao@uth.tmc.edu

View on ClinicalTrials.gov More Acute, Perforated Appendicitis trials