Effect of Azithromycin on Failure Proportion of Severe Periodontitis Non-surgical Treatment

Inclusion Criteria: * Patient with severe generalized chronic periodontitis (loss of attachment ≥ 5mm at \> 30% sites) (AAP classification 1999) and periodontal pockets \>5mm on at least 5% of sites * presence of bleeding on probing (≥ 30%) * male or female subject older than 35 Years * patient with at least 15 teeth including at least 2 molars (excluding wisdom teeth) * patient with social assurance * voluntary patient who signed informed consent Exclusion Criteria: * Patient with contraindications to treatment with azithromycin or its excipient: absolute contraindications are the history of allergy to macrolides or one of the excipients used in this study, association with ergot derivatives Rye, Cisapride, colchicine, and severe hepatic deficiencies. Other contraindications are for patients at risk of cardiac arrhythmia (diagnosis of QT interval prolongation and/or concomitant treatments, electrolytic disorder (hypokalemia, hypomagnesemia, cardiac arrhythmia, heart failure), severe renal failure, and drug associations (Antivitamin K, statins) * Patient with aggressive periodontitis (AAP classification 1999) * Patient smoking more than 10 cigarettes/day * Patient with endocarditis risk or requiring antibiotic prophylaxis * Patient with antibiotic treatment within 6 months prior to periodontal examination * Patient with anti-inflammatory treatment in the month preceding periodontal examination and/or anti-inflammatory treatment of more than 3 consecutive days in the 3 mont…