Active — Not RecruitingNot Applicable

Ethnic Differences in Iron Absorption (FeGenes)

United States515 participantsStarted 2019-08-01

Plain-language summary

This study aims to; 1) investigate population differences in iron absorption between East Asians and Northern Europeans; 2) assess population differences in hormonal and biochemical determinants of Fe absorption between East Asians and Northern Europeans; and 3) to investigate genetic contributions to Fe absorption, Fe status and Fe regulatory hormones between East Asians and Northern Europeans.

Who can participate

Age range18 Years – 50 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Healthy adults * Age between 18- 50y * Non-smoking * Not taking vitamin or mineral supplements. * Females: premenopausal and not pregnant or lactating * No preexisting medical complications (such as eating disorders, hemoglobinopathies, malabsorption diseases, steroid use, substance abuse history, or taking medications known to influence iron homeostasis) * Body mass index (BMI) between 18 - 30 kg/m2. Exclusion Criteria: * BMI \<18 or \> 30 kg/m2, * Age \<18 y or \> 50y, * Not of Northern European or East Asian ancestry * Smoking * Pregnancy, lactating * Have gastrointestinal disorders/malabsorption diseases/hemoglobinopathies/dietary restrictions/steroid use/ medication use of medications known to impact iron status, iron utilization or inflammatory status * Take vitamin and mineral supplementations

What they're measuring

The percent of non-heme iron absorption

Timeframe: 2-week

The concentrations of iron and micronutrient status indicators

Timeframe: baseline and two-weeks post dosing

Genetic ancestry and characterization of iron-related genotypes

Timeframe: baseline

Habitual dietary information

Timeframe: baseline

Dietary information on the study day

Timeframe: baseline

Trial details

NCT IDNCT04198545

SponsorCornell University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2023-10-16

View on ClinicalTrials.gov More Anemia, Iron Deficiency trials

Plain-language summary

Who can participate

Age range18 Years – 50 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

The percent of non-heme iron absorption

Timeframe: 2-week

The concentrations of iron and micronutrient status indicators

Timeframe: baseline and two-weeks post dosing

Genetic ancestry and characterization of iron-related genotypes

Timeframe: baseline

Habitual dietary information

Timeframe: baseline

Dietary information on the study day

Timeframe: baseline