Stopped: Following further collection and analysis of temporal binding data, we found the relationship between PSS and clinical outcomes to not be strong enough for adaptation.
Multiple sensory cues are typically generated by discrete events, and while they do not reach the cerebrum simultaneously, the brain can bind them temporally if they are interpreted as corresponding to a single event. The temporal binding of vestibular and non-vestibular sensory cues is poorly understood and has not been studied in detail, despite the fact that the vestibular system operates in an inherently multimodal environment. In this study, the researchers are investigating the physiology and pathophysiology of vestibular temporal binding by studying normal subjects, patients with peripheral and central vestibular dysfunction, and patients with vestibular and cochlear signals provided by prosthetic implants in the inner ear.
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Changes in postural sway/balance
Timeframe: baseline and post-PSS adaptation (1 hour)
Change in rapid measure of gait
Timeframe: baseline and post-PSS adaptation (1 hour)
Change in measure of inducible dizziness
Timeframe: baseline and post-PSS adaptation (1 hour)
Change in Point of Subjective Simultaneity (PSS)
Timeframe: baseline and 1 hour post 8-hour VI-CI 'physiologic' stimulation