Liver Transplant for Stable, Advanced Intrahepatic Cholangiocarcinoma

Inclusion Criteria: * Male or female, aged 18 years or older, at time of consent * Eastern Cooperative Oncology Group (ECOG) score : 0 or 1 at all times from study entry to LT * Able and willing to provide written informed consent. * Women of child-bearing potential must agree to use adequate birth control * Histologically-confirmed diagnosis of iCCa * Disease is deemed unresectable based on tumor location or underlying liver dysfunction * No vascular invasion, extra-hepatic disease, or lymph node involvement detected on imaging * Patients must have ≥ 6 months of disease stability or tumor regression on gemcitabine-based therapy. For patients who have progressed to second-line therapy, disease must also be controlled for ≥ 6 months on that regimen * At least 1 living donor has stepped forward, is blood group compatible and has completed a "Health History form" which, upon review by the Living Donor team, is deemed acceptable and demonstrates no obvious contraindications to donation. Exclusion Criteria: * Previous or concurrent cancer (some exceptions permitted) * Patients who have extrahepatic metastases, lymph node involvement, invasion or encasement of major hepatic vascular structures, perforation of the visceral peritoneum, invasion of extrahepatic structures, invasion of perihilar fat, periductular invasion, concurrent hepatoma or mixed hepatocellular cholangiocarcinoma * Patients having received prior locoregional therapies or radiation to the tumor * Renal dysfuncti…