This study will incorporate critical cross viscero-visceral intersystem interactions to 1) investigate in a controlled laboratory setting and then with mobile at-home monitoring the extent, severity, and frequency of occurrence of autonomic dysreflexia with respect to daily bladder and bowel function, in conjunction with identifying potential underlying mechanisms by examining urinary biomarkers for several specific vasoactive hormones, and 2) to regulate cardiovascular function therapeutically as part of bladder and bowel management using spinal cord epidural stimulation.
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19.1194 Will determine change in systolic blood pressure during filling during cystometry
Timeframe: 2 hours
19.1194 Will determine maximum change in systolic blood pressure during Anorectal Manometry assessments
Timeframe: 1 hour
17.1024 BB-IS-2 Change from baseline in systolic blood pressure over a 24 hour period after 80 sessions (6 months)
Timeframe: 6 months