UnknownNot Applicable

RV Systolic and Diastolic Function and Contractile Reserve Under Acute Exercise and in Response to Chronic Exercise-based Rehabilitation

Germany84 participantsStarted 2022-07-01

Plain-language summary

Exercise training in Pulmonary arterial hypertension in the setting of rehabilitation leads to an enormous improvement of functional state and haemodynamics. However the underlying mechanism is still unkown. It is assumed to be relied on Right ventricular contractile reserve, but this has never been proven with goldstandard PV-loop assessment. Our aim is to evaluate the mechanism leading to the increase in functional state and to evaluate the impact of exercise (acute and chronic) on right ventricular performance

Who can participate

Age range18 Years – 75 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Consent form, * men and women\> 18 years \<75 years * invasively confirmed chronic PH who have received complete diagnostic evaluation by specialized physicians according to at a center for pulmonary hypertension and were adjusted for 2 months under intensive medical therapy and are stable Exclusion Criteria: * Pregnancy or lactation, * Change in medication during the last 2 months, * Patients with signs of right heart decompensation, severe walking disturbance, * No previous invasively confirmation of PH, acute diseases, Infections, fever, * active myocarditis, unstable angina pectoris, exercise-induced ventricular -arrhythmias, congestive heart failure, significant heart disease, pacemakers, and -hypertrophic obstructive cardiomyopathy, or a highly reduced left ventricular function

What they're measuring

Primary endpoint will be the change in baseline Ees over the 15 weeks observation period

Timeframe: over 15 weeks

Trial details

NCT IDNCT04188756

SponsorUniversity of Giessen

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-02-01