A Gender and Culturally Specific Approach to Reduce NAFLD in Mexican-American Men

Inclusion Criteria: * Self-identify as a Mexican or Mexican-American man * 18-64 years of age * BMI between 30 to 50.0 kg/m² * Have a CAP score ≥248 at screening * Be identified as PNPLA3 risk allele carriers (CG/GG genotype) at screening * Be able to provide informed consent * Speak, read, and write either English and/or Spanish. Exclusion Criteria: * Have active, chronic gastrointestinal disorder (e.g. inflammatory bowel disease, ulcerative colitis, Chron's disease, celiac disease) * Been previously diagnosed with viral hepatitis, liver disease or liver cancer * Have a history of bariatric surgery * Report medical condition or treatment for a medical condition that could affect body weight or ability to engage in structured physical activity that is consistent with the intervention for this study * Have current congestive heart failure, angina, uncontrolled arrhythmia, or other symptoms indicative of an increased acute risk for a cardiovascular event * Have a resting systolic blood pressure of ≥150 mmHg or resting diastolic blood pressure of ≥100 mmHg * Have an eating disorders that would contraindicate weight loss or physical activity * Report significant alcohol consumption (e.g., drinking ≥ 21 standard drinks/week, binge drinkers, or those with previous heavy alcohol consumption) identified by the Alcohol Use Disorders Identification Test * Currently treated for psychological issues (e.g., depression, bipolar disorder, etc.), taking psychotropic medications with the p…