Characterizing Chemo-Radiotherapy Treatment-Related Cardiac Changes

Inclusion Criteria: * Age \>= 18 years * Planned standard of care curative thoracic RT or CRT with anticipated heart V40 \> 20 cc (At least 20 cc of the heart should receive a dose of 40 gray \[Gy\] or higher) * Able to follow-up at all specified standard of care time-points * Patients can receive treatment as part of the standard of care or in a different study * Receiving radiation treatment to an area close to the heart, for example gastroesophageal junction cancer, hilar lung cancer, or mainstem bronchus lung cancer * Any type of systemic therapy or surgery before during or after radiation is acceptable * Prior radiation to other areas is acceptable * Planned radiation doses equal or higher than 40 Gy Exclusion Criteria: * Metastatic disease * Recurrent disease * Patient receiving radiation prescription doses lower than 40 Gy * No prior radiation that included any part of the heart is acceptable * No thoracic re-irradiation