TerminatedPhase 4

Predicting SSRI Efficacy in Veterans With PTSD

Stopped: difficulty meeting recruitment goals

United States26 participantsStarted 2019-09-11

Plain-language summary

This is a research study to examine the effectiveness of a brief screening method that may predict which people with posttraumatic stress disorder (PTSD) or depression are most likely to show a positive response to selective serotonin reuptake inhibitor (SSRI) medications. Participants will be recruited over approximately 5.25 years, until at least 94 participants complete the 17 week study.

Who can participate

Age range18 Years – 75 Years

SexALL

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Inclusion criteria

✓. has a history of trauma exposure as defined by criterion A of PTSD in the DSM-5
✓. meets diagnostic criteria for PTSD, subthreshold PTSD, or MDD as defined by DSM-5
✓. study psychiatrist's judgment that SSRIs are an acceptable treatment option for the participant's presenting concerns, and
✓. interest in starting a trial of an SSRI

What they're measuring

Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) Change

Timeframe: Administered at screening session 1, and weeks 0, 2, 6, and 14

Trial details

NCT IDNCT04183205

SponsorVA Office of Research and Development

Sponsor typeFED

Study typeINTERVENTIONAL

Primary completion2025-03-30

View on ClinicalTrials.gov More Posttraumatic Stress Disorder trials