CompletedEarly Phase 1

Age Comparisons of Exercising Muscle O2 Supply in Healthy Adults: Effects of Esmolol Infusion

United States30 participantsStarted 2022-02-02

Plain-language summary

This study will test the central hypothesis that postmenopausal women will demonstrate increased oxygen extraction in active leg muscle during leg cycling exercise while receiving an infusion of Esmolol, a fast-acting β1 selective antagonist, when compared to premenopausal women

Who can participate

Age range18 Years – 75 Years

SexFEMALE

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Inclusion criteria

✓. Capable of giving informed consent
✓. Premenopausal women ages 18-35 years OR post-menopausal women ages 55-70 years
✓. Satisfactory medical history and physical exam, as determined by a Clinical Research Center (CRC) clinician
✓. Not currently taking medications affecting heart rate or contractility
✓. Fluent in written and spoken English

Exclusion criteria

✕. Are less than 19 years of age or more than 70 years of age
✕. Are pregnant or lactating
✕. Are prisoners or institutionalized individuals or unable to consent
✕. Diagnosed renal failure (Creatinine \>2.0 mg/dl)
✕. Diagnosed liver disease (ALT and aspartate aminotransferase {AST} 2 times normal)
✕. Diagnosed Reynaud's disease
✕. Have uncontrolled diabetes
✕. Have uncontrolled hypertension

What they're measuring

Tissue Saturation Index (TSI) - Active Leg Muscle

Timeframe: Last 60 seconds of Rest, Moderate exercise, and Heavy Exercise.

Trial details

NCT IDNCT04181606

SponsorDavid N. Proctor, PhD

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-04-25

Results submitted2024-06-26

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