CompletedNot Applicable

Improving Gait Adaptability in Hereditary Spastic Paraplegia

Netherlands36 participantsStarted 2019-12-01

Plain-language summary

This study evaluates the effects of ten hours C-mill training on gait adaptability in participants with hereditary spastic paraplegia (HSP). Half of the participants start with five weeks of C-mill training (ten 1-hour sessions). The other participants are placed on a waiting list, which is followed by the same five weeks of C-mill training (ten 1-hour sessions). It is hypothesized that ten hours of context specific C-mill training is effective in improving gait adaptability in participants with pure HSP.

Who can participate

Age range18 Years – 70 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria: * Diagnosis of pure-HSP based on molecular diagnosis or based on inheritance pattern * Aged between 18-70 years old * Being able to walk barefoot on a level ground for 50 meters without a walking aid (use of orthopaedic devices or made-to-measure footwear is allowed). Exclusion criteria: * Other neurological or serious orthopaedic or psychiatric co-morbidity * Previous HSP-related surgical interventions of the lower extremities.

What they're measuring

The mean changes in time scores of the obstacle subtask of the emory functional ambulation profile

Timeframe: Pre-intervention (week 0) till post-intervention (week 6)

Trial details

NCT IDNCT04180098

SponsorRadboud University Medical Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-04-15

View on ClinicalTrials.gov More Hereditary Spastic Paraplegia trials