Cognitive and Brain Development in Adolescents With Gilles de la Tourette Syndrome (NCT04179435) | Clinical Trial Compass
CompletedNot Applicable
Cognitive and Brain Development in Adolescents With Gilles de la Tourette Syndrome
France132 participantsStarted 2019-12-11
Plain-language summary
In children with neurodevelopmental disorders, adolescence is usually associated with a reshaping of the clinical picture and symptomatology. Tourette syndrome (TS) is a paradigmal neurodevelopmental syndrome characterised by involuntary paroxysmal movements (motor tics) and vocalisation (vocal tics) often associated with various psychiatric disorders. The neuronal and cognitive mechanisms associated with TS symptoms improvement during adolescence, or the persistence in adulthood remains unknown, and this is what we aim to address in this study.
Who can participate
Age range
13 Years – 18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Tourette syndrome
* Ages 13 - 18
* Acceptance to perform the Brain MRI
* Acceptance to perform the cognitive testing
* Acceptance to perform the TMS measures
Exclusion Criteria:
* Learning disability
* Incompatibility with MRI procedure (metal body implants, pregnancy)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Behavioral test main outcome measures [1]
Timeframe: from 16 to 20 months
2
Behavioral test main outcome measures [2]
Timeframe: from 16 to 20 months
3
Behavioral test main outcome measures [3]
Timeframe: from 16 to 20 months
4
Behavioral test main outcome measures [4]
Timeframe: from 16 to 20 months
5
Brain MRI scan measures
Timeframe: from 16 to 20 months
6
Transcranial magnetic stimulation
Timeframe: from 16 to 20 months
Trial details
NCT IDNCT04179435
SponsorInstitut National de la Santé Et de la Recherche Médicale, France