UnknownPhase 1/2

Can Levothyroxine Treatment Reduce the Development of Cardio-metabolic Disorder in Subclinical Hypothyroidism?

40 participantsStarted 2020-01

Plain-language summary

2\. Aim/ Objectives The aim of this study is to evaluate the clinical, laboratory and echocardiographic findings in children with SCH. To investigate the effect of replacement therapy with levothyroxine on cardiovascular risk factors in children with SCH.

Who can participate

Age range5 Years – 15 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * 1\. Patients aged from 5-15 years diagnosed with SH (patients with elevated TSH and normal Ft4 on two different measurements 4-6 weeks apart). Exclusion Criteria: * 1\. Patients with acute or chronic disorders (anemia, infection, diabetes mellitus, malignancy, liver and renal disorder). 2\. Patients with a history of medication that affect thyroid function tests as glucocorticoids, dopamine or dobutamine, amiodarone, lithium, interferons, alemtuzumab. 3\. Patients with BMI\>95 percentile.

What they're measuring

: Normalization of TSH.

Timeframe: 12 week

Trial details

NCT IDNCT04178928

SponsorAin Shams University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-01

Contact for this trial

Nashwa MOhamed Abd elwahab, MSCof pediatrics

01061487888 nashwa.abotaleb@gmail.com

View on ClinicalTrials.gov More Subclinical hypothyroïdism trials