Molecular and Organizational Changes in the Human Oral Mucosa During Aging (NCT04178668) | Clinical Trial Compass
TerminatedNot Applicable
Molecular and Organizational Changes in the Human Oral Mucosa During Aging
Stopped: Difficulty in recruitment
France38 participantsStarted 2020-03-11
Plain-language summary
The objective of this interventional with mucosa et saliva samples, monocentric, transversal and pilot study is to extract vibrational, thermal and dielectric markers obtained by Differential Scanning Calorimetry, Thermo-Stimulated Currents and Fourier Transform Infrared spectroscopy on oral mucosa and saliva samples collected from 66 patients divided in two groups (20-40 and 70-90 years old).
Who can participate
Age range
20 Years – 90 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patient requiring a classic dental surgery (extraction, implantology...) at the Toulouse University Hospital,
* Between the ages of 20 and 40 or between 70 and 90 years
Exclusion Criteria:
* Patient with gastrotomy probes or chemotherapy, palliative care (or with a life expectancy of less than 30 days),
* Patient with surgical contraindication: allergy to local anesthetics, major hemorrhagic risk: patient on unbalanced Anti Vitamin K, patient on new anticoagulants not relayed or not discontinued,
* Patient at high risk of infectious endocarditis
* Patient under safeguard of justice.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Vibrational marker of the oral mucosa: collagen 1 fraction indicator
Timeframe: Day 0
2
Vibrational marker of the oral mucosa : collagen 2 fraction indicator
Timeframe: Day 0
3
Thermal marker of the oral mucosa : percentage of open water
Timeframe: Day 0
4
Thermal marker of the oral mucosa: percentage of water related
Timeframe: Day 0
5
Thermal marker of the oral mucosa : percentage of total water
Timeframe: Day 0
6
Thermal marker of the oral mucosa : maximum denaturation temperature
Timeframe: Day 0
7
Thermal marker of the oral mucosa : collagen denaturation enthalpy