Entolimod on Immunosenescence in Healthy Geriatric Subjects Receiving Influenza Vaccination

Inclusion: * Men and women of age 65 years and older at the time of enrollment * Eligible to receive Fluzone High-Dose * Female subjects must be past menopause and not pregnant * No history of anaphylactic reaction to gelatin, neomycin, or other vaccine component * Must not have had the flu vaccine within the past 90 days * Medically stable with no exacerbations or changes in medication regimen for chronic diseases in the past 3 months and no hospitalizations in the past 6 months * Must be able to read/write English in order to provide informed consent and comply with study procedures * Expected to be available for the duration of the study Exclusion: * Receipt of any other vaccines within the past 30 days prior to enrollment * Acute illness within the last 7 days * History of hypersensitivity to the flu vaccine or its components (including gelatin, formaldehyde, octoxinol, thimerosal, and chicken protein). * History of Guillain Barré syndrome (GBS) * History of bleeding disorders * Medical contraindication to treatment with vaccine as indicated by a history of autoimmune disease, immune deficiency, or hypersensitivity to other vaccines. * Unstable major cardiovascular, renal, endocrine, immunological or hepatic disorder * Systolic blood pressure (SBP) \< 110 mmHg or orthostatic hypotension \[\>20 mmHg fall in SBP or \>10 mmHg fall in diastolic blood pressure (DBP) with standing\] at the time of screening. * Evidence of an ongoing systemic bacterial, fungal, or viral infec…