The aim of this study to evaluate the patients who underwent controlled hypotensive anesthesia under standardized depth of anesthesia; preoperative and postoperative blood HIF 1a, TAS, TOS measurement and cerebral perfusion evaluation with NIRS and to investigate tissue hypoxia secondary to hypotensive anesthesia and the changes of the mediators at the tissue level and which blood pressure parameters are related.
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Evaluation of the relationship between hypotensive anesthesia technique and brain hypoxia by the rate of NIRS
Timeframe: intraoperative 2 hours
Evaluation of the relationship between hypotensive anesthesia technique and tissue hypoxia by HIF1a
Timeframe: Change from Baseline HIF 1a at 2 hours
Evaluation of the relationship between hypotensive anesthesia technique and tissue hypoxia by the concentration of TAS
Timeframe: Change from Baseline TAS levels at 2 hours
Evaluation of the relationship between hypotensive anesthesia technique and tissue hypoxia by the concentration of TOS
Timeframe: Change from Baseline TOS levels at 2 hours