Change in Airway Peripheral Tone in COPD (NCT04166812) | Clinical Trial Compass
UnknownNot Applicable
Change in Airway Peripheral Tone in COPD
Germany150 participantsStarted 2019-11-19
Plain-language summary
Small airways disease is a pathological feature in mild to moderate COPD, which might be causally involved in disease progression. However, there are only limited studies available that prospectively identified patients at risk for small airway disease. Our intention is to investigate the early phase of the disease. In addition, we thereby want to build up a well-defined study population of patients in an early phase of the disease with a rapid decrease in lung function as measured by oscillometry and multiple breath washout (MBW)-testing. In addition, it is our goal to identify patients in an early stage of disease and patients at risk of fast progression and/or rapid decline in lung function.
Who can participate
Age range
35 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
patients at risk for COPD
inclusion criteria:
* smoking history (at least 10 pack years)
* absence of airway obstruction (FEV1/FVC ≥ 70% after salbutamol 400µg)
* high symptom score (CAT ≥ 10) or long acting bronchodilator therapy
* age \> 35 years
exclusion criteria:
* respiratory infection within 4 weeks prior to inclusion
* other symptomatic pulmonary disease, except bronchial asthma
patients with early COPD
inclusion criteria:
* smoking history (at least 10 pack years)
* mild COPD (FEV1/FVC \< 70% and FEV1 ≥ 70% after salbutamol 400µg)
* age \> 35 years
exclusion criteria:
* respiratory infection within 4 weeks prior to inclusion
* other pulmonary disease, except bronchial asthma
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.