Efficiency and Changes of Cytokines Expression in Tear After Intense Pulsed Light Treating Dry Eye Disease

Inclusion Criteria: * Subject is able to read, understand and sign an Informed Consent (IC) form * 18-100 years of age * Subject is able and willing to comply with the treatment/follow-up (FU) schedule and requirements * In the study eye, tear break up time ≤ 7 seconds * In the study eye, Meibomian Gland Score (MGS) ≤ 12 * In the study eye, at least 5 non-atrophied meibomian glands in the lower eyelid * Symptoms self-assessed using the Ocular Surface Disease Index (OSDI) questionnaire ≥ 23 Exclusion Criteria: * Fitzpatrick skin type V or VI * Contact lens wear within the month prior to screening * Unwilling to discontinue use of contact lenses for the duration of the study * Ocular surgery or eyelid surgery, within 6 months prior to screening * Neuro-paralysis in the planned treatment area, within 6 months prior to screening * Other uncontrolled eye disorders affecting the ocular surface, for example active allergies * Current use of punctal plugs * Pre-cancerous lesions, skin cancer or pigmented lesions in the planned treatment area * Uncontrolled infections or uncontrolled immunosuppressive diseases * Subjects with ocular infections, within 6 months prior to screening * Prior history of cold sores or rashes in the perioral area or in the planned treatment area that could be stimulated by light at a wavelength of 560 nm to 1200 nm, including: Herpes simplex 1 \& 2, Systemic Lupus erythematosus, and porphyria * Within 3 months prior to screening, use of photosensitive medi…