UnknownPhase 4

Phenobarbital vs Ativan for Alcohol Withdrawal in the Intensive Care Unit

United States142 participantsStarted 2020-07-06

Plain-language summary

Our aim is to compare outcomes of patients with benzodiazepine-refractory alcohol withdrawal syndrome who are treated with either a phenobarbital-based or a lorazepam based protocol.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. has required more than 10 mg of lorazepam within a one hour time period,
✓. has required more than 30 mg of lorazepam within a four hour time period, or
✓. requires admission/transfer to the intensive care unit for primarily uncontrolled alcohol withdrawal symptoms

Exclusion criteria

✕. has a traumatic brain injury or other neurological condition requiring frequent neurological assessment (stroke, intracranial hemorrhage, active seizures on admission)
✕. has severe hypotension requiring vasopressor support
✕. is less than 18 years of age
✕. is actively pregnant
✕. has an allergy to either of the drugs being studied (phenobarbital or lorazepam)
✕. is already intubated at the time of randomization

What they're measuring

ICU length of stay

Timeframe: study completion, up to 18 months

Trial details

NCT IDNCT04156464

SponsorOSF Healthcare System

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-12-01

Contact for this trial

Rachael M Davis, MD

309-655-7257 rachael.m.davis@osfhealthcare.org

View on ClinicalTrials.gov More Alcohol Withdrawal trials