CompletedNot Applicable

Measuring Immune Tolerance to Predict Miscarriage or Failed Embryo Transfer

United States56 participantsStarted 2019-08-23

Plain-language summary

Pregnancy is a unique period which requires alterations in the immune system to allow for tolerance of a haploidentical fetus. The goal of this study is to measure maternal blood levels of proteins known to promote immune tolerance in early implantation and pregnancy to look for associations between tolerance, miscarriage and failed embryo transfer. Establishing predictive factors of miscarriage and failed in vitro fertilization could have implications for a large portion of couples and serve to guide current and future family planning efforts.

Who can participate

Age range18 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Females, 18 years old or older * Patients undergoing a frozen embryo transfer OR confirmed intrauterine pregnancy between 5 0/7 weeks and 9 6/7 weeks gestation * Patients planning to have all bloodwork done at Mayo Clinic Rochester * Patients planning to deliver at Mayo Clinic or within the Mayo Clinic Health Systems Exclusion Criteria: * Non English speaking * Pregnancy with multiple fetuses * Patient has non-viable pregnancy

What they're measuring

Spontaneous Conception Cohort: change in immune tolerance, as measured by Enzyme Linked Immunosorbent Assay (ELISA)

Timeframe: Baseline (6-12 weeks gestation)

Infertility Cohort: change in immune tolerance, as measured by Enzyme Linked Immunosorbent Assay (ELISA)

Timeframe: Change from baseline (day of transfer) at Day 11

Trial details

NCT IDNCT04156126

SponsorMayo Clinic

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-06-01

View on ClinicalTrials.gov More Infertility trials