Active — Not RecruitingNot Applicable

Acute Health Effects of Traffic-Related Air Pollution Exposure

China69 participantsStarted 2019-10-09

Plain-language summary

This study aims to assess the effects of acute exposure to traffic-related air pollution and the underlying mechanisms.

Who can participate

Age range

18 Years – 30 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Living in Shanghai during the study period; * Body mass index \> 18.5 and ≤ 28; * Non-smoking, no history of alcohol or drug abuse; * Completing the walking task we required. Exclusion Criteria: * Current or ever smokers; * Subjects with allergic disease, such as allergic rhinitis, allergic asthma, and atopy; * Subjects with cardiovascular disease, such as congenital heart disease, pulmonary heart disease, and hypertension; * Subjects with respiratory disease, such as asthma, chronic bronchitis, and chronic obstructive pulmonary disease; * Subjects wih chronic disease, such as diabetes, chronic hepatitis, and kidney disease; * Subjects with a history of major surgery; * Abnormal spirometry (FEV1 and FVC ≤ 75% of predicted and FEV1/FVC ≤ 0.65); * Medication use or dietary supplements intake in recent two months;

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Changes in FEV1

Timeframe: FEV1 will be examined before exposure, half an hour after exposure and 12 hours after exposure.

Blood Pressure

Timeframe: Blood pressure will be measured for 24 hours from 8:00 am on the morning of intervention to 8:00 am on the next morning.

Heart Rate Variability Parameters

Timeframe: Volunteers will be asked to wear electrographic Holter monitors for 24 hours from 8:00 am on the morning of intervention to 8:00 am on the next morning.

Trial details

NCT IDNCT04153539

SponsorFudan University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-12-08

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