Active — Not RecruitingNot Applicable

Identification of Genetic Causes of Calcific Aortic Valve Disease

United States1,000 participantsStarted 2018-09-25

Plain-language summary

This study aims to identify the molecular genetic causes of the variability in development of calcific aortic valve disease in bicuspid and tricuspid aortic valves and their associated aortic dilation.

Who can participate

Age range20 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients with a plan to undergo elective aortic valve replacement and/or ascending aortic surgery Exclusion Criteria: * Age \< 20 years * Unable/unwilling to consent * History of aortic valve replacement or transcatheter aortic valve replacement (TAVR) * History of endocarditis * History of rheumatic fever * History of chest radiotherapy * History of organ transplant

What they're measuring

Identification of expression signatures of aortic valve development and calcification in the macroscopically normal and abnormal portions of aortic valves excised during aortic valve replacement.

Timeframe: 8 years

Trial details

NCT IDNCT04149600

SponsorBeth Israel Deaconess Medical Center

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-06-30

View on ClinicalTrials.gov More Calcific Aortic Stenosis trials