UnknownNot Applicable

The Association Between Calretinin and the Function of Ganglion Cells in Hirschsprung Disease

Canada50 participantsStarted 2020-05-01

Plain-language summary

This study aims to compare the outcomes of patients with long segment Hirschsprung disease or total colonic aganglionosis who had negative calretinin staining and positive ganglion cells on the proximal resection margins to those who had both positive findings.

Who can participate

Age range0 Years – 18 Months

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Confirmed histopathological diagnosis of Hirschsprung disease from January 1, 1990 to August 31, 2019 * Long-segment Hirschsprung disease (type A and B) * Total colonic aganglionosis (TCA) * Surgery at CHUSJ * Tissue blocks of proximal resection margin available for pathological analysis * Minimum 1 month of postoperative follow-up Exclusion Criteria: * Short-segment Hirschsprung disease (conventional form, rectosigmoid junction) * Total colonic with small bowel aganglionosis (TCSA) * Surgery done at another institution * Early deaths * Lost to follow-up * No documented post-operative outcome

What they're measuring

Long-term outcomes (Quality of life questionnaire)

Timeframe: 1 year

Trial details

NCT IDNCT04149093

SponsorSt. Justine's Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-09-01

View on ClinicalTrials.gov More Hirschsprung Disease trials