WithdrawnNot Applicable

Impact of Preoxygenation Time on End-tidal Oxygen Concentration and on Hypoxic Events Occurring After Intubation in the Intensive Care Unit.

Stopped: No inclusion after the 2 years of approval of the human subject review, even after 2 years of prorogation

France0Started 2023-12

Plain-language summary

Preoxygenation is recommended before performing tracheal intubation. In intensive care units (ICU) patients, there is no specific recommendation regarding the duration of preoxygenation, which usually is applied for 3 to 5 minutes. Monitoring the effectiveness of preoxygenation with end-tidal oxygen concentration (EtO2) is strongly recommended in the operating room but it is never used in ICUs. The first aim of this pilot study is to assess the effect of the preoxygenation duration on EtO2, and secondarily, as an exploratory objective, to determine whether targeting a given value of EtO2 during preoxygenation might insure a safer intubation than when targeting pulse oximetry (SpO2).

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients older than 18 years * Requiring intubation in ICU * Free express oral and informed consent of the patient or a proxy in case of impossibility for the patient to consent; emergency inclusion possible when legal representatives and patient's family are not present Exclusion Criteria: * Intubation for cardiac arrest * End-tidal oxygen concentration monitoring not available * Preoxygenation with high-flow nasal oxygenation * Previous participation to the study * Patient known, at time of inclusion, as being under guardianship, tutorship or curator * Pregnancy or breastfeeding * Lack of social security number

What they're measuring

Percentage of patients who reach an EtO2 of 90%

Timeframe: 3 minutes

Trial details

NCT IDNCT04148443

SponsorCentre Hospitalier Régional d'Orléans

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-12