TerminatedPhase 4

Cilostazol and Nimodipine Combined Therapy After Aneurysmal Subarachnoid Hemorrhage (aSAH)

Stopped: Insufficient recruitment

United States19 participantsStarted 2019-11-01

Plain-language summary

The investigators seek to demonstrate that the combined use of cilostazol and nimodipine will significantly decrease the rate of delayed cerebral infarction and cerebral vasospasm after cerebrovascular intervention when compared to nimodipine alone.

Who can participate

Age range

18 Years – 100 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * 18 years of age or older * Anterior circulation aneurysm * Patients who have undergone surgical intervention * Absence of rebleeding or new intracranial hemorrhage noted on post-intervention CT scan * Consent for study participation Exclusion Criteria: * Non-aneurysmal subarachnoid hemorrhage * Multiple ruptured aneurysms * Patients with congestive heart failure * Severe aneurysmal subarachnoid hemorrhage (Hunt Hess Grade V) * Active pathological bleeding * Allergy to cilostazol * Positive pregnancy test * Coagulopathy not caused by anti-coagulant use * History of hemorrhagic complications (gastrointestinal bleeding, etc) * Uncontrolled or severe comorbidity that would qualify as an absolute contraindication for cilostazol * Patients requiring anticoagulant/antiplatelet treatment following intervention (e.g. stent-assisted coiling or flow-diverting stent obliteration of aneurysm)

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Delayed Cerebral Infarction

Timeframe: Baseline

Delayed Cerebral Infarction

Timeframe: 1 week (+/- 2 days) postoperatively

Delayed Cerebral Infarction

Timeframe: 1 month (+/- 7 days) postoperatively

Trial details

NCT IDNCT04148105

SponsorHenry Ford Health System

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-05-21

View on ClinicalTrials.gov More Aneurysmal Subarachnoid Hemorrhage trials

Who can participate

Age range

18 Years – 100 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.