The DIAMOND study aims to investigate the presence and diagnostic relevance of potential biomarkers of the blood-nerve barrier disruption as surrogate markers of painful post-traumatic trigeminal neuropathic pain in patients presenting with neuropathic odontalgia. The first part of the study explores the proof-of-concept and technical feasibility of intra-epithelial nerve fiber immunostaining in gingival/oral mucosa biopsies and the potential presence of these biomarkers in healthy patients (baseline condition).
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Patched-1 Western Blot concentration
Timeframe: Baseline
Patched-1 immunohistochemistry concentration
Timeframe: Baseline
Patched-1 ELISA concentration
Timeframe: Baseline
Frizzled-7 Western Blot concentration
Timeframe: Baseline
Frizzled-7 immunohistochemistry concentration
Timeframe: Baseline
Frizzled-7 ELISA concentration
Timeframe: Baseline
Claudin-5 Western Blot concentration
Timeframe: Baseline
Claudin-5 immunohistochemistry concentration
Timeframe: Baseline
Claudin-5 ELISA concentration
Timeframe: Baseline