The DIAMOND study aims to investigate the presence and diagnostic relevance of potential biomarkers of the blood-nerve barrier disruption as surrogate markers of painful post-traumatic trigeminal neuropathic pain in patients presenting with neuropathic odontalgia. The first part of the study explores the proof-of-concept and technical feasibility of intra-epithelial nerve fiber immunostaining in gingival/oral mucosa biopsies and the potential presence of these biomarkers in healthy patients (baseline condition).
Age range
18 Years
Sex
ALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Patched-1 Western Blot concentration
Timeframe: Baseline
Patched-1 immunohistochemistry concentration
Timeframe: Baseline
Patched-1 ELISA concentration
Timeframe: Baseline
Frizzled-7 Western Blot concentration
Timeframe: Baseline
Frizzled-7 immunohistochemistry concentration
Timeframe: Baseline
Frizzled-7 ELISA concentration
Timeframe: Baseline
Claudin-5 Western Blot concentration
Timeframe: Baseline
Claudin-5 immunohistochemistry concentration
Timeframe: Baseline
Claudin-5 ELISA concentration
Timeframe: Baseline