Effects of Exercise on Glymphatic Functioning and Neurobehavioral Correlates in Parkinson's Disease

Inclusion Criteria: * Participant has Parkinson's disease as defined by the UK Brain Bank Criteria. * Patient has demonstrated a positive levodopa or related therapy response. * Participant is willing and able to participate in a Rock Steady Boxing class. * Participation reports a typically sedentary lifestyle in the 6 months prior to enrollment, i.e., no daily-to-weekly, guided, aerobic or non-aerobic exercise routine. * Participant agreeable to an overnight dopaminergic medication washout period. * Subject has an identified, reliable method of attending study appointments and Rock Steady Boxing classes. Exclusion Criteria: * Clinical Dementia Rating scale score \<=1 * Any contraindication or inability to tolerate brain magnetic resonance imaging (MRI) or medical conditions that may interfere with their ability to enter the scanner and/or interfere with interpretation of acquired MRI scanning data (e.g., a pacemaker or any other implanted device or condition that would preclude proximity to a strong magnetic field). * Any contraindication to overnight dopaminergic medication washout period. * Any contraindication to participation in Rock Steady Boxing. * Subject resides at a skilled nursing or dementia care facility, or admission to such a facility is planned during the study period. * Signs or symptoms of untreated obstructive sleep apnea (i.e., 3+ of the 8 STOP-Bang OSA items). Treatment-compliant OSA patients will not be excluded. * Signs of MSA, probable Al…