VItamin C in Thermal injuRY: The VICToRY Trial (NCT04138394) | Clinical Trial Compass
SuspendedPhase 3
VItamin C in Thermal injuRY: The VICToRY Trial
Stopped: After the 1st interim analysis, on the recommendation of the DSMC, the steering committee decided to stop enrollment of new patients. The study is ongoing for the currently enrolled patients. More info to follow when available for public disclosure.
United States, Belgium, Canada666 participantsStarted 2020-07-24
Plain-language summary
This study aims to show that giving high dose, intravenous vitamin C in addition to standard care to burned critically ill patients will be associated with less organ dysfunction, improved survival and a quicker rate of recovery. In this study, all patients will receive standard care and of the patients will also receive high dose intravenous vitamin C, while the other half of patients will receive placebo.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* 18 years of age or older
* Deep 2nd and/or 3rd degree burns requiring skin grafting
* Minimum burn size of ≥ 20% Total Body Surface Area (TBSA)
Exclusion Criteria:
* \>24 hours from admission to participating hospital to consent.
* Patients admitted to burn unit \>24 from injury or accident.
* Patients who are moribund (not expected to survive the next 72 hours).
* Pregnancy (pregnancy will be ruled out as part of standard of care) or lactating.
* Enrollment in another industry sponsored ICU intervention study.
* Receiving high-dose IV vitamin C already (enteral or oral vitamin C is allowed).
* Known glucose-6-phosphate dehydrogenase (G6PD) deficiency.
* Recent history of kidney stones (within the last year).
* Concomitant use of hydroxycobalamin (vitamin B12) for suspected cyanide poisoning.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Persistent Organ Dysfunction + Death
Timeframe: at 28 days
Trial details
NCT IDNCT04138394
SponsorClinical Evaluation Research Unit at Kingston General Hospital