TerminatedNot Applicable

Efficacy of Volume Ventilation in Patients With Acute Respiratory Failure at Risk of Obstructive Apneas or Obesity Hypoventilation

Stopped: Difficulty in enrolling new patients

France14 participantsStarted 2019-12-04

Plain-language summary

This study compares a volume targeted pressure support non-invasive ventilation with an automatic PEP regulation (AVAPS-AE mode) to a pressure support non-invasive ventilation (S/T mode) in patients with acute hypercapnic respiratory failure with acidosis. This study focuses on patients at risk of obstructive apneas or obesity-hypoventilation syndrom (BMI≥30 kg/m²). Half of participants (33 patients) will receive non invasive ventilation with AVAPS-AE mode, the other half will receive non-invasive ventilation with S/T mode.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * Patient of age * Patient benefitting of social security * Informed patient who signed the information note and the research enlighted consent form * Admission in respiratory intensive care unit for an acid-hypercapnic exacerbation (defined by pH≤ 7,35) * BMI ≥ 30kg/m2 * PaCO2 \> 6.5 kPa on blood gases at ICU admission Exclusion Criteria: * Confirmed COPD with a spirometry (VEMS/CVF \< 70%) * Pregnant women, or breast-feeding women * Patient with a judiciary or administrative liberty deprivation * Patients under guardianship * Contraindication to NIV

What they're measuring

Resolution of hypercapnia

Timeframe: through study completion, an average of 1 year

Trial details

NCT IDNCT04131660

SponsorUniversity Hospital, Rouen

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-06-30

View on ClinicalTrials.gov More Acute Respiratory Failure trials