4Kscore Using Serum Stored Uncentrifuged

Inclusion Criteria: * Men capable of donating five 5 mL tubes of whole blood * 40 to 80 years old * No prior diagnosis of prostate cancer; prior negative prostate biopsy included * Total PSA (tPSA) value measured within last year to be: at 1.5 ng/mL to 4 ng/mL, 4.1 ng/mL to 10 ng/mL and 10 ng/mL and above Exclusion Criteria: * In the previous 96 hours (4 days), underwent a digital rectal exam * Any invasive urologic procedure in the 6 months prior to study participation * Underwent any procedure to treat symptomatic benign prostatic hyperplasia in the last 6 months * Radical prostatectomy since tPSA measurement * Received within the previous 6 months 5-alpha reductase inhibitor (5-ARI) therapy such as Avodart (dutasteride) or Proscar (finasteride)