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A Study on Central Transport Characteristics of Flurbiprofen Axetil in Elderly Patients

China77 participantsStarted 2019-10

Plain-language summary

The project will apply the methods of clinical observation experiment to study the central transport characteristics of flurbiprofen axetil by detecting S-flurbiprofen and R-flurbiprofen concentrations in cerebral-spinal fluid(CSF) after intravenous injection of flurbiprofen axetil in elderly patients.

Who can participate

Age range18 Years – 85 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients undergoing lower extremity surgery under spinal or combined spinal-epidural anesthesia will be selected. Exclusion Criteria: * asthma, liver insufficiency, renal insufficiency, peptic ulcer, allergy to NSAIDs, and a history use of NSAIDs within two weeks before operation.

What they're measuring

The concentrations of S-flurbiprofen and R-flurbiprofen in plasma and CSF of all patients.

Timeframe: perioperation

Trial details

NCT IDNCT04128410

SponsorYi Feng, MD

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2019-10

Contact for this trial

Yi Feng, MD

08601088325590 yifeng65@sina.com

View on ClinicalTrials.gov More Flurbiprofen Axetil trials