Is 10 Injections of Bladder Botox Less Painful Than 20 Injections?

Inclusion Criteria: * Female gender * At least 18 years of age * Have already decided to undergo intradetrusor Botox® injections for treatment of refractory overactive bladder. * Able and willing to learn clean intermittent catheterization (or care provider is willing and able to perform intermittent catheterization). * Understands and is willing to undergo follow up and complete questionnaires as described in this protocol * Able to give informed consent Exclusion Criteria: * Male gender * Neurological conditions (Examples: Cerebral vascular accident within 6 months prior to treatment, Parkinson's disease, Multiple Sclerosis, and Spina Bifida). * Acute urinary tract infection * Treatment with Botox® toxin for other conditions * Allergy to Botox® toxin * Hematuria that has not been worked up * Known bladder malignancy * Previous history of bladder augmentation * Currently pregnant (with no plans to become pregnant within 6 months of enrollment) or breastfeeding * Currently taking aminoglycoside antibiotics * Post-void residual (PVR) \>150 cc (measured by bladder scan or by catheterization) prior to enrollment * History of chronic pain or pain syndromes