Behavioral Pharmacology of Cannabis and Nicotine

Inclusion Criteria: * Have provided written informed consent * Be between the ages of 18 and 55 * Be in good general health based on a physical examination, medical history, vital signs, and screening urine and blood tests * Test negative for drugs of abuse aside from cannabis (via urine sample) and alcohol (via breath sample) at the screening visit and upon arrival for each experimental session. * Not be pregnant or nursing (if female). All females must have a negative serum pregnancy test at the screening visit and a negative urine pregnancy test at clinic admission. * Have a body mass index (BMI) in the range of 18 to 36 kg/m2 * Blood pressure at screening visit does not exceed a systolic blood pressure (SBP) of 150 mmHg or a diastolic blood pressure (DBP) of 90 mmHg * Have not donated blood in the prior 30 days. * Report prior experience inhaling cannabis. * Report using cannabis at least 5 times in the past year. * Smoke ≥5 tobacco cigarettes per day on average in the past month. * Use an e-cigarette at least 15 of the past 30 days. * Have a breath carbon monoxide (CO) of \>8ppm or urine cotinine \>200ng/mL to confirm current nicotine use status. Exclusion Criteria: * Non-medical use of psychoactive drugs (aside from cannabis) other than, nicotine, alcohol, or caffeine in the month prior to the Screening Visit; * History of or current evidence of significant medical or psychiatric illness which, in the opinion of the investigator or sponsor, will interfere with the st…