CompletedNot Applicable

rTMS to Enhance Cognitive Performance and Promote Resilience

United States38 participantsStarted 2019-11-21

Plain-language summary

The purpose of this study is to determine the most effective dose of brief, non-invasive brain stimulation (repetitive transcranial magnetic stimulation, rTMS) for improving cognitive functions such as attention and memory as well as to improve the ability to recover from stressful situations (stress resilience).

Who can participate

Age range22 Years – 55 Years

SexALL

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Inclusion criteria

✓. No history of mental or physical illness
✓. No implanted metal in the body
✓. College graduates (Associates degree or higher)
✓. Negative urine pregnancy test, if female subject of childbearing potential
✓. Able to read and understand questionnaires and informed consent

Exclusion criteria

✕. Any current psychiatric diagnosis or current Clinical Global Impression ratings of psychiatric illness \> 1
✕. Current physical illness
✕. History of CNS disease, concussion, overnight hospitalization, tumors, seizures, meningitis, encephalitis, abnormal CT/MRI of the brain
✕. Moderate to severe traumatic brain injury (TBI)
✕. History of a continuing significant laboratory finding
✕. Frequent or severe headaches
✕. Any history of psychotropic medication prior to study enrollment
✕. Females of childbearing potential who are pregnant (by urine HCG), nursing, or who are not using a reliable form of birth control.

What they're measuring

Mean Score of Neurocognitive Performance (Fluid Cognition)

Timeframe: Baseline (Day 1)

Change From Baseline in Neurocognitive Performance at 1 Week Post Treatment (Fluid Cognition)

Timeframe: Post-treatment (within 1 week of completing rTMS)

Change From Baseline in Neurocognitive Performance at 1 Month Post Treatment (Fluid Cognition)

Timeframe: Post-treatment (within 1 month of completing rTMS)

Trial details

NCT IDNCT04123496

SponsorMedical University of South Carolina

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-09-27

Results submitted2022-09-28

View on ClinicalTrials.gov More Cognition trials