Inflammation plays an important role in the pathogenesis of peritoneal carcinosis. Patients with elevated levels of different inflammation cytokines show a worse prognosis at the time of diagnosis. In women, ovarian and colon cancer are the main causes of peritoneal carcinosis and a comparison of these two different types of peritoneal invasion have not been conducted yet. We found interesting studying the role of immune response, in particular tumour-associated antigens (TAA) that modulate the metastatic process. We will investigate also mitochondrial defects, such as mutations in mt-DNA, potentially involved in carcinogenesis.
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Immune biomarkers level
Timeframe: Each patients will be assessed at baseline
Metastatic mediators level
Timeframe: Each patients will be assessed at baseline
P2X7R-inflammasome activity
Timeframe: Each patients will be assessed at baseline