WithdrawnNot Applicable

Hyperbaric Oxygen for Carbon Monoxide Induced Chronic Encephalopathy

Stopped: no funding

0Started 2023-06-06

Plain-language summary

In some patients, a few days or weeks after recovery from carbon monoxide poisoning, new symptoms develop. These can affect mood, ability to think or remember clearly, and movements. Some people develop movement problems that are similar to Parkinson's disease. This damage to brain tissue is called "encephalopathy," and this study will look at the effect of pressurized oxygen therapy on long term, or chronic, encephalopathy.

Who can participate

Age range10 Years – 90 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * CO induced neurological or cognitive sequelae assessed as at least mild (e.g. UPDRS part 3 (motor)\>15). * chronicity- signs or symptoms present for greater than one year after exposure. Exclusion Criteria: * age \>90 or less than 10 years * other morbidities which may contribute to chronic neurocognitive deficits (such as traumatic brain injury, poisoning by other toxins, other neurodegenerative diseases) * pregnancy (if a subject becomes pregnant she will be removed from the study) * routine contraindications to hyperbaric oxygen

What they're measuring

Short Form (36) Health Survey

Timeframe: 4 months (after 80 treatments)

Trial details

NCT IDNCT04118491

SponsorUniversity of Nebraska

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-06-06

View on ClinicalTrials.gov More Carbon Monoxide Poisoning trials