Treatment of Female Genital Schistosomiasis (FGS) With Praziquantel: A Proof-of-Concept Study

Inclusion Criteria: * Women 15 to 35 years of age with a gynaecological/urinary/lower abdominal complaint * The woman has signed the informed consent form (IFC); in the case of minors, the IFC has to be signed by parent or guardian. * The woman does not plan to leave the area within 6 months and accept to come to the CSB regularly following the scheduled follow-up (at week 5,10 and 15). * The woman with confirmed diagnosed of FGS (as described in section 6.3.1) * The woman agrees to be examined clinically and gynaecologically including taking specimens from the genital tract (collection of vaginal lavage fluid, collection of cells with a cytobrush). * The woman agrees to provide a urine and a stool sample. * The woman agrees that a venous blood sample for laboratory assessments is taken. * The woman accepts to stay at the hospital for 2 days follow-up after the first dose of PZQ. Exclusion Criteria: * Virgin (assessed by gynaecologist) * Pregnancy (determined by pregnancy test) * Tumor of vulva, vagina, uterus (diagnosed by gynaecologist) * Treatment with praziquantel during the last 3 months * Hysterectomy * Known HIV positive prior to enrollment * Any severe medical condition requiring hospitalization * The woman is unable to comprehend the nature and objectives of the study * The woman is judged by the investigators to be unlikely to participate regularly in the follow-up * The woman is taking any drug that might affect the metabolism of PZQ and that is contraindicated …