Active — Not RecruitingNot Applicable

Personalizing Osteoporosis Care: Clinical & Genetic Risk Factors for AFFs

Canada1,200 participantsStarted 2018-06-25

Plain-language summary

The overall objective of this project is to identify clinical and genetic risk factors for Atypical Femur Fractures (AFFs) in Anti-resorptive therapy (ART) users by conducting a case control study of 330 cases of AFFs and 660 controls without AFFs matched for age, sex, race and duration of ART.

Who can participate

Age range18 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Cases: Have experienced a confirmed, documented Atypical femur fracture * Controls: currently on anti-resorptive therapy, matches AFF case by age, race and length of ART use Exclusion Criteria: \-

What they're measuring

Associations between AFF and clinical Risk Factor

Timeframe: baseline

Associations between AFF and common genetic variants

Timeframe: baseline

Validation of top genetic variants

Timeframe: baseline

Trial details

NCT IDNCT04110795

SponsorUniversity Health Network, Toronto

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-12-31

View on ClinicalTrials.gov More Atypical Femur Fracture trials