Metabolic, Functional and Nutritional Responses to Weight Cycling in Athletes: The WAVE Study (NCT04107545) | Clinical Trial Compass
CompletedNot Applicable
Metabolic, Functional and Nutritional Responses to Weight Cycling in Athletes: The WAVE Study
France48 participantsStarted 2021-05-03
Plain-language summary
Many elite athletes are submitted to frequent rapid weight loss periods to meet their competition weight category and then experience weight cycling (lowing and gaining weight regularly). This weight cycling induce severe temporary energetic and metabolic changes and when repeated over time can lead to permanent metabolic adaptations that might favor metabolic disorders, body weight gain and body composition changes (favoring fat mass). The exact effects of this weight cycling are not clear yet, especially in terms of metabolic, energetics, nutritional functional and psychological impacts. Better understand these adaptations and their variations during weight loss and weight gain in regular weight cycler is of main importance to prevent these athletes for future health issues.
The aim of the present project if to assess these metabolic, functional, energetic and nutritional adaptations during weight loss, weight stable and weight gain periods in athletes experiencing regular weight cycling.
Who can participate
Age range
18 Years – 35 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Subjects aged 18 to 35 (inclusive),
* exercising at least 4 sessions of endurance or weight-based sporting activities per week for a performance objective,
* having variations of at least 5% of their weight body during the last 3 sporting seasons (a sporting season corresponds to a year during which alternates the periods of training, recovery and participation in official competitions).
* Subject capable of providing informed consent to participate
* Subject with a social security insurance.
Exclusion Criteria:
* Medical or surgical history deemed by the investigator to be incompatible with the study.
* Presence of chronic pathology.
* Disorders of eating behavior.
* Subjects born very prematurely defined as a pregnancy inferior to 28 weeks.
* Subjects having used a treatment for a small stature (eg growth hormone).
* For women: irregular menstruation (changes in menstrual cycles ≥ 6 days).
* Sports subjects with a stable weight during the last three sporting seasons (weight variation \<5%).
* Take medication that can change body temperature.
* Pregnant or lactating women.
* Subjects with gastrointestinal complications and / or contraindications to ingestion of the capsule (eg diverticulosis, inflammatory bowel disease, gastrointestinal surgery ...).
* Subjects needing MRI during ingestion of the capsule or having a pacemaker or other implanted electro-medical device.
* Person under guardianship or not subject to a social security scheme.
* Refusal t…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.