Predicting Endometrial Receptivity for Optimal Reproductive Management
United States76 participantsStarted 2020-07-01
Plain-language summary
The purpose of this study is to understand why some women are infertile (unable to conceive a child). The investigators hope to learn if an endometrial biopsy after egg retrieval is feasible for detecting biomarkers for endometriosis and predicting implantation and pregnancy rate after embryo transfer.
This study design will provide for the first time, an opportunity to compare endometrial biopsy material from hyperstimulated (gonadotropin treated) subjects after egg retrieval. If successful, it would provide a new protocol for women with unexplained infertility or those with known endometriosis to avoid poor IVF outcomes.
Who can participate
Age range18 Years – 42 Years
SexFEMALE
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Inclusion criteria
✓. Age - 18 to 42
✓. AMH ≥ 1
✓. Planning to undergo IVF with delayed embryo transfer
✓. Must have blastocyst(s) by day 6 that were biopsied for PGT-A
✓. BMI 18-35
Exclusion criteria
✕. Uterine fibroids \> 4 cm in size
✕. Polycystic ovary syndrome (PCOS) according with the Rotterdam criteria.
✕. Ovarian failure and subjects receiving donor oocytes/embryos
✕. Anti-cardiolipid and/or lupus anti-coagulant abnormalities by history