CLUE is a prospective study to determine structural and functional changes of brain and spinal cord, as well as the inflammatory environment in patients with neuroinflammatory and demyelination disease. Participants will receive new magnetic resonance (MR) technics including double inversion recovery (DIR) imaging diffusion kurtosis imaging (DKI), quantitative susceptibility mapping (QSM) and resting-state functional imaging and follow up for one year using 3T MRI. In addition, participants will receive T1WI, T2WI, FLAIR and SWI sequences on 7T MRI.
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The brain structural change over time between the baseline MRI and the follow-up MRIs
Timeframe: On admission to the hospital on day 1, on discharge 180 days later and on follow up 360 days later
The spinal cord change over time between the baseline MRI and the follow-up MRIs.
Timeframe: On admission to the hospital on day 1, on discharge 180 days later and on follow up 360 days later
The functional change over time between the baseline MRI and the follow-up MRIs.
Timeframe: On admission to the hospital on day 1, on discharge 180 days later and on follow up 360 days later