UnknownNot Applicable

Biomarkers of Common Eye Diseases

China220 participantsStarted 2019-09-26

Plain-language summary

To identify biomarkers of common eye diseases based on single-cell sequencing technologies using PBMC samples. These diseases include uveitis, diabetic retinopathy, age-related macular degeneration and polypoid choroidal vasculopathy. Our study may provide new insight into the underlying mechanisms, and reveal novel predictors and intervention targets for the diagnosis, prognosis and treatment of these diseases.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Age over 18 (including 18 years old);
✓. Clinically diagnosed as diabetic retinopathy (DR), uveitis (VKH or BD) , age-related macular degeneration (AMD) , or polypoid choroidal vasculopathy (PCV)

Exclusion criteria

✕. Have received more than 2 intravitreal injections of anti-VEGF drugs because of retinal or choroidal neovascularization and macular edema;
✕. Patients with stable condition after having undergone panretinal laser photocoagulation and pars plana vitrectomy (PPV);
✕. There are other serious systemic diseases of the body, such as history of chronic kidney disease requiring dialysis or a kidney transplant, unstable blood pressure, cardiovascular disease, tumors, etc;
✕. Patients who are pregnant or nursing

What they're measuring

Peripheral blood mononuclear cell (PBMC) signatures

Timeframe: 1 year

Trial details

NCT IDNCT04101604

SponsorSun Yat-sen University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2020-10-01

Contact for this trial

Yingfeng Zheng

+8613922286455 zhyfeng@mail.sysu.edu.cn

View on ClinicalTrials.gov More Uveitis trials