CompletedNot Applicable

Multisystem and Autonomic Complications of NMD on Long-term NIV

United Kingdom35 participantsStarted 2019-10-25

Plain-language summary

This exploratory observational study evaluates autonomic function using measures including heart rate variability in adults with childhood-onset neuromuscular and neurological disorders (NMD) who use non-invasive ventilation (NIV) as part of their long-term care. Autonomic function will be correlated with measures of symptom burden, disease severity and complications.

Who can participate

Age range16 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Patient group: * Age ≥16 years * Confirmed diagnosis of childhood-onset NMD * Able and willing to provide informed consent * Requires non-invasive ventilation on an intermittent or continuous basis to manage respiratory failure Reference group: * Age ≥16 years * No significant co-morbidities * Not on any regular medications * Able and willing to provide informed consent Exclusion Criteria: * Inability to travel to hospital site * Clinical instability or acute deterioration requiring hospitalisation or changes to medication in the previous 4 weeks * A female of child-bearing potential who is pregnant or intends to become pregnant during study involvement

What they're measuring

Heart rate variability (HRV)

Timeframe: 1 day

Trial details

NCT IDNCT04100993

SponsorRoyal Brompton & Harefield NHS Foundation Trust

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-05-20

View on ClinicalTrials.gov More Neuromuscular Diseases trials