The primary objectives are to characterize changes in indices of systemic and gut inflammation, assess host- and microbial-derived metabolite pools, and describe and link functional metagenomics and metatranscriptomic alterations in the gut microbiome with metabolite and inflammatory outcomes after acute (24hr) and chronic (4 week) intake of anthocyanins and ellagitannins from strawberry and red raspberries compared to a control diet (negative control), FOS (positive control, non-polyphenol, carbohydrate-based fermentable fiber/pre-biotic), or combination diet (berry composite + FOS) in human participants with low-grade inflammation.
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Changes in plasma biomarkers and measures of inflammation concentration: Nrf2/ NF-κB -response between 4 treatments
Timeframe: Baseline to 4 weeks
Changes in plasma biomarkers and measures of inflammation concentration-response between 4 treatments
Timeframe: Baseline to 4 weeks
Changes in plasma biomarkers and measures of inflammation concentration (GLP-2)-response between 4 treatments
Timeframe: Baseline to 4 weeks