PremiCron Suture for Cardiac Valve Repair

Inclusion Criteria: * Patients undergoing an elective primary open or minimal invasive surgery for a single or multiple cardiac valve reconstruction or / and replacement. * Age ≥18 years * Written informed consent Exclusion Criteria: * Patients undergoing an elective primary cardiac valve reconstruction or / and replacement in combination with a coronary arterial bypass graft surgery. * Emergency surgery * Pregnancy * Infective endocarditis * Previous cardiac surgical intervention * Known immunodeficiency or immunosuppression * Participation or planned participation in another cardiovascular study before study follow-up is completed. * Inability to give informed consent due to mental condition, mental retardation, or language barrier.