Home Airway Clearance in CF Patients

Inclusion Criteria: * Patient diagnosed with Cystic fibrosis * Stabilization of the disease, defined by an at least 4 weeks period since the end of an exacerbation, stabilization will be let to investigator's judgment. * Age \>12 * Requiring at least 1 bronchial clearing session each week (regardless of the technique) * Patient (or patient's legal representative if applicable), capable to read and understand the procedure, and capable to express consent for the study protocol. Exclusion Criteria: * Severe pneumothorax or hemoptysis (more than 30ml per 24 hours) within 6 weeks before the inclusion day. * Patient placed on a transplant waiting list * Any contraindication to an instrumental bronchial clearance technique * Patients already own and use SIMEOX at home * Unavailable patient or patient wishing to move to a different region within three months after inclusion. * Patient currently participating or having participated to another interventional clinical research within a month prior inclusion date, that may impact the study, this impact is left to the investigator's judgment. * Persons referred by the French Public Health Code to Articles L1121-5 to L1121-8 (includes all protected persons: pregnant women (confirmed by measurement of the serum human chorionic gonadotropin level for any woman wishing to enter the protocol and under childbearing age \< 60), parturient woman, breastfeeding mother, everyone deprived of his liberty by judicial or administrative decision, ev…