CompletedPhase 4

Cabergoline Before or After Oocyte Collection for Follicular Resolution

United States70 participantsStarted 2019-09-23

Plain-language summary

Randomized trial comparing the efficacy of two different times of administration of cabergoline in patients undergoing controlled ovarian stimulation and oocyte collection.

Who can participate

Age range18 Years

SexFEMALE

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Inclusion criteria

✓. Adult female at least 18 years of age intending to undergo ovarian stimulation for a cycle of IVF.
✓. Ability read and understand English sufficiently to obtain informed consent and complete a study diary.
✓. Pre-implantation genetic screening (PGS) is allowed.
✓. Egg donors are allowed.
✓. Patients using a gestational carrier are allowed.
✓. Patients with prior IVF cycles are allowed, but no patient can undergo more than one cycle with oocyte collection under this study.

Exclusion criteria

✕. Egg banking, donor egg banking, or any cycle type that would preclude immediate culture to blastocyst stage.
✕. Patients that would be unavailable for the follow-up ultrasound 5 days post-retrieval, such as patients that live far from the clinic (e.g. out of state).
✕. Uncontrolled hypertension.
✕. Ergot alkaloid hypersensitivity or allergy.
✕. History of pulmonary, pericardial, retroperitoneal fibrotic disorders.
✕. History of bipolar disorder, schizophrenia, or psychotic illness.
✕. Breast feeding.
✕. History of eclampsia or pre-eclampsia.

What they're measuring

Discomfort level

Timeframe: 5 days after egg collection

Mature oocyte rate per follicular puncture

Timeframe: Within 24 hours of egg collection

Trial details

NCT IDNCT04096027

SponsorFertility Center of Las Vegas

Sponsor typeINDUSTRY

Study typeINTERVENTIONAL

Primary completion2021-06-10

View on ClinicalTrials.gov More Infertility, Female trials